Chapter 12 Links
The Human Genome Project

Human Genome Project

• Middlebury College Human Genome Information Page
  • This is a great looking site with neat extras such as the Human Genome Opinion Poll.
• Human Genome Project Information
  • Explore this site for material about the history, progress, research, and resources of the Human Genome Project.
• The Human Genome Project
  • From the National Human Genome Research Institute, this site explains what the project is, when it began, and what its mission is. It also includes links to resources.
• Human Genome Program
  • The Human Genome Program of the Department of Energy is a focused effort to reach the goals of the U.S. Human Genome Project in cooperation with the extramural division of the National Center for Human Genome Research of the National Institutes of Health.

Francis Collins

• Where Science and Religion Meet
  • Scientific American article featuring a profile and biography of the current head of the Human Genome Project, and how he reconciles his work in cutting-edge science with his strong belief in God.

Renato Dulbecco

• Renato Dulbecco (1914- )
  • A short review which includes a vita, synoposis, and references.
• Renato Dulbecco
  • There is a picture here and also a description of his current research.
• Laboratory of Gene Therapy - Renato Dulbecco

Charles DeLisi

• Charles DeLisi
  • Here is a description of his current research and a photo.

National Organizations

These three organizations have nicely designed pages with a lot of information

• National Academy of Sciences
• National Human Genome Research Institute (NHGRI)
• National Institute of Health (NIH)

Escherichia coli

• Bugs in the News - What the Heck is an E. coli?
  • E. coli info from the great biology education resources of the U of Kansas.
• The E. coli Index
  • A comprehensive guide to information relating to the bacterium Escherichia coli on the WWW.
• Escherichia coli
  • Here there are two pictures of E. coli growing on eosin methylene blue (EMB) agar.
• E. coli 0157:H7 Infection
  • Similar to the "What the Heck is.." site, but it provides extra information.
• Preventing Foodborne Illness: Escherichia coli O157:H7
  • Questions and answers from the CDC.
• E. Coli Primer
  • E. coli infection from a legal perspective.

Saccharomyces cerevisiae

• What are yeasts?
  • An introduction to all types of yeast.
• Molecular Biology of Brewers Yeast
  • A good site with many good links.
• Yeast Molecular Genetics
  • A brief description into the use of yeast in experiments.
• You Can & Yeast
  • Highly recommended! This site explains how yeast makes bread rise and it tells you how to grow yeast and make bread.
• Yeast Experiments
  • These articles describe genetics and radiation experiments using yeast (Saccharomyces cerevisiae), a popular eukaryotic microbe for genetics and molecular biology research. They include student experiments and techniques, teacher tips, background material, integrated applications to environmental science, math, and physics, and sources of supplies.

Caenorhabditis elegans

• An introduction for those unfamiliar with 'The Worm'
  • This brief introduction explains what C. elegans are, why they are studied, and it includes a biological thumbnail sketch.
• Caenorhabditis elegans WWW Server
  • Lots of links.
• The Strome Lab
  • For a more advanced audience, this site includes some neat photos and a video archive if you can figure what they're showing.

Drosophilia melanogaster

• Latin School of Chicago Drosophila melanogaster Site
  • This is a great site of information about all aspects of Drosophilia including reproductive cycle, gender differences, crosses, anesthetizing, varieties, storage, and habitat. Highly recommended!
• SEM Images of Drosophila melanogaster
  • Cool images from the Scanning Electron Microscope.

Arabidopsis thaliana

• Arabidopsis web site
  • Neat looking site with great images.
• Multinational Coordinated Arabidopsis Thaliana Genome Research Project
  • This is the fourth annual report to summarize the achievements of the Multinational Coordinated Arabidopsis thaliana Genome Research Project. It includes traditional scientific reports as well as a collection of brief articles prepared for a more general audience.
• The Meyerowitz Lab Home Page

Zea mays

• The Maize Page
  • All-around great site from our own Iowa State University.
• Corn
  • A description of corn for a general audience.
• About Corn
  • A very good overview of corn.
• Biology of Corn
  • An essay describing the taxonomy, morphology, reproduction, pollination, and cultivation of corn.

Mus musculus

• Mus musculus (House mouse)
  • Written for a general audience, this site includes information on classification, geographic range, physical characteristics, natural history, conservation/biodiversity, and economic benefits for humans.
• The House of Mouse
  • This is not a scientific site, but a fun place to learn all about mice.

Jean Dausset

• Jean Dausset
  • A short biography.
• Fondation Jean Dausset -CEPH
  • The Centre d'Etudes du Polymorphisme Humain (CEPH) is a research laboratory created in 1984 by Professor Jean Dausset (Nobel Prize, medicine and physiology, 1980). This laboratory constructs maps of the human genome.

Ethics Research

• The Center for Bioethics
  • The Center for Bioethics is an interdisciplinary, interprofessional unit of the University of Pennsylvania Health System in Philadelphia. The Center's mission is to advance scholarly and public understanding of ethical, legal, social and public policy issues in health care.
• The Research Ethics Section of the Ethics Center for Engineering & Science
  • This site includes Learning Research Ethics as a Community - a series of activities for student-faculty learning, including original scenarios, discussion and interview questions, and readings. There are also links to other sites.
• Science Conduct On-Line
  • This site is no longer interactive, but you can still read the information. The magazine Science invited five experts in science conduct to provide ethical scenarios that pose complex decisions. Readers responded to them and the experts posted a response.
• Foundation for Biomedical Research
  • The Foundation for Biomedical Research (FBR) was established in 1981 to improve the quality of human and animal health by promoting public understanding and support of the ethical use of animals in scientific and medical research.

Restriction Fragment Length Polymorphism (RFLP)

• How RFLPs Can Help Find a Faulty Gene
  • This is a short article from Access Excellence. It doesn't go into much detail so it mostly serves as an introduction to what RFLPs are and what they're used for.
• Restriction Fragment Length Polymorphisms (RFLPs)
  • A discussion of RFLPs and their uses.
• DNA Goes to Court
  • Go to the next page to find a discussion of RFLPs.

Yeast Artificial Chromosomes (YAC)

• Yeast Artificial Chromosomes
  • Here is a brief description of YACs.
• The YACs are Here!
  • From Access Excellence, this site has a good introduction including a graphic demonstrating cloning into a YAC.

Maynard Olson

• The Turning Point in Genome Research
  • This article describes Olson's role in genome research.
• A Time to Sequence
  • An article by Olson himself at Science's Policy Forum.

Telomere

• What are Telomeres?
  • This introductory site is highly recommended.
• Telomere Findings May Yield Tips For Treating Cancer, Geriatric Disorders
  • A February 19, 1996 article discussing the importance of telomere findings.
• Alexey M. Olovnikov
  • Homepage of the founder of the telomere loss theory of aging.
• Science News Digest for Physicians and Scientists
  • Summarizing telomeres and includes many links.

Daniel Cohen

• Daniel Cohen To Join GENSET
  • February 7,1996 - GENSET S.A., today announced that Professor Daniel Cohen, M.D., who led a team of researchers responsible for generating the first physical mapping of the human genome, will join GENSET as General Manager of Genome Research. GENSET is a global genomics company, with the purpose of accelerating drug discovery through comprehensive genomic sequencing and analysis.

Human Chromosome 21

• Chromosome 21 (AD1)
  • Summary of the involvement of chromosome 21 in Alzheimer's Disease and Down's Syndrome.

Chromosome Y

• Men Haven't Changed in 270,000 Years
  • A survey of genetic information contained in the Y chromosomes of modern day men suggests that Homo sapiens descended from a single group of male ancestors, and that this occurred more recently than previously believed.

Sanger Method or Dideoxy Chain-Termination Method

• Method: Sequencing of Double Stranded DNA Using Dideoxy Chain Termination
  • Go to this site to read about the principle behind the technique.
• DNA Sequencing Figure
  • The simple figure demonstrates how the sequence is read.
• DNA Sequencing Simulation (Sanger Method)
  • This lab will simulate the Sanger method of sequencing DNA, both visually and kinesthetically. It should be used in conjunction with a reading on Sanger sequencing. This simulation uses colored pop-beads, which represent nucleotides and dideoxynucleotides.